Endocrine Abstracts

As known, the number of obese people in the world exceeds 50% of the total population. Тo search the causes of obesity development many researchers pay attention to metabolites of intestinal microflora among which the main ones are short–chain fatty acids (SCFA): acetate (C2), propionate(C3), butyrate(C4). Hormones of food behavior produced by visceral adipose tissue (leptin) and cells of the gastrointestinal tract (ghrelin) also play an important role in the devel...

Introduction: Retinol binding protein (RSP) is a member of the adipokine family associated with insulin resistance (IR). With an excess of free fatty acids, the binding of insulin by hepatocyte receptors decreases and hyperinsulinemia develops. RSP is a transport protein for retinol, synthesized in hepatocytes and adipocytes. The level of RSP increased in patients with obesity, diabetes mellitus and non-alcoholic fatty liver disease (NAFLD) correlated positively with the sever...

Pathogenesis of Non-alcoholic fatty liver disease in 90% combined with diabetes mellitus (DM) of the second type. Factors cutting: abdominal obesity, excessive content of free fatty acids. Development of insulin resistance through protein kinase. Violation of the transmission of insulin signal leads to damage to the endothelium. Glycation of nitric oxide synthase leads to the development of diabetic complications and violates the sensitivity of the insulin receptors.<p cla...

Obesity affects on the composition of bile: the lithogenicity of bile increases, biliary sludge and cholelithiasis are developing. Under the influence of the active form of oxygen, abnormal forms of bile acids are formed, which negatively affects the development and progression of the pathological process. With the development of inflammation in the liver and pancreas, disturbances in the membrane proteins of glucose transporters occur, the activity of nuclear receptors for th...

Retinol binding protein (RBP) is an adipokine, related to insulin resistance (IR). Excess free fat acid reduces the binding of insulin by hepatocyte receptors and leads to hyperinsulinemia. RBP transport protein synthesized in hepatocytes and adipocytes. The level of RBP increases in patients with obesity, diabetes and non-alcoholic fatty liver disease (NAFLD). It is positively correlated with the degree of severity of the inflammatory process and fibrosis. The RBP regulates t...

Retinol binding protein (RBP) is an adipokine, related to insulin resistance (IR). Excess free fat acid reduces the binding of insulin by hepatocyte receptors and leads to hyperinsulinemia. RBP transport protein synthesized in hepatocytes and adipocytes. The level of RBP increases in patients with obesity, diabetes andnon-alcoholic fatty liver disease (NAFLD). It is positively correlated with the degree of severity of the inflammatory process and fibrosis. The RBP regulates th...

Purpose of researchTo determine the level of insulin content, the content of nitric oxide metabolites, Malondialdehyde, the activity of lipoprotein-associated phospholipase A2 (FLA2), in the blood serum of patients with NFLD with type II D and impaired glucose tolerance.Material and methodsThe study included 74 patients with non-alcoholic fatty liver disease. 30 of them have diabetes of the second type, and 3...